12/21/2023 0 Comments Side effect of metforminGastrointestinal (GI) side effects were markedly reduced in patients randomised to met-DR vs. A non-significant reduction in mean body weight was observed in individuals randomized to met-XR vs. There was no significant difference between the efficacy of met-IR, met-XR or met-DR in changing FPG ( p = 0.93). ![]() Resultsįifteen studies ( n = 3765) met eligibility criteria. Meta-analyses were conducted using random-effects models. Outcome measures were change in fasting plasma glucose (FPG), glycated haemoglobin (HbA1c), body weight, BMI, lipid profile and side effects. Two reviewers independently assessed articles for eligibility and risk-of-bias, with conflicts resolved by a third reviewer. Trials that randomized adult participants to extended-release formulation of metformin (met-XR), delayed-release (met-DR) or immediate-release metformin (met-IR) were included. PubMed, Web of Science, OVID EMBASE, MEDLINE, The Cochrane database and were systematically searched (from inception to 25 January 2021). Slower-release formulations of metformin may reduce the incidence of side effects while maintaining efficacy however, there is a lack of systematic evidence available to guide head-to-head comparisons between different metformin formulations. Although metformin has several important advantages, for example being easy to store and administer, it is associated with a high incidence of gastrointestinal side effects. ![]() Metformin is among the most frequently prescribed drugs worldwide for a variety of indications.
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